Package: httkexamples
Version: 0.0.1
Date: 2025-12-03
Title: High-Throughput Toxicokinetics Examples
Description: High throughput toxicokinetics ("HTTK") is the combination
        of 1) chemical-specific in vitro measurements or in silico
        predictions and 2) generic mathematical models, to predict
        absorption, distribution, metabolism, and excretion by the
        body. HTTK methods have been described by Pearce et al. (2017)
        (<doi:10.18637/jss.v079.i04>) and Breen et al. (2021)
        (<doi:10.1080/17425255.2021.1935867>). Here we provide examples
        (vignettes) applying HTTK to solve various problems in
        bioinformatics, toxicology, and exposure science. In accordance
        with Davidson-Fritz et al. (2025)
        (<doi:10.1371/journal.pone.0321321>), whenever a new HTTK model
        is developed, the code to generate the figures evaluating that
        model is added as a new vignettte.
Authors@R: c(
           person("John", "Wambaugh", email = "john.wambaugh@UL.org", 
             role = c("aut", "cre"),
             comment = c(ORCID = "0000-0002-4024-534X")), 
           person("Robert", "Pearce", role = c("aut"),
             comment = c(ORCID = "0000-0003-3168-4049")), 
           person("Caroline", "Ring", email = "Ring.Caroline@epa.gov", 
             role = c("aut"), comment = c(ORCID = "0000-0002-0463-1251")), 
           person("Greg", "Honda", email = "honda.gregory@epa.gov", 
             role = c("aut"), comment = c(ORCID = "0000-0001-7713-9850")), 
           person("Matt", "Linakis", email = "MLINAKIS@ramboll.com", 
             role = c("aut"), comment = c(ORCID = "0000-0003-0526-2395")), 
           person("Dustin", "Kapraun", email = "kapraun.dustin@epa.gov",
             role = c("aut"), comment = c(ORCID= "0000-0001-5570-6383")),
           person("Kimberly", "Truong", email = "truong.kimberly@epa.gov", 
             role = c("aut"), comment = c(ORCID = "0000-0003-1716-1006")), 
           person("Meredith", "Scherer", email="Scherer.Meredith@epa.gov",
             role = c("aut"), comment = c(ORCID = "0000-0002-9785-7363")),
           person("Annabel", "Meade", email = "aemeade7@gmail.com",
             role = c("aut"), comment = c(ORCID = "0000-0002-5452-8797")),
           person("Celia", "Schacht", email="Schacht.Celia@epa.gov",
             role = c("aut"), comment = c(ORCID = "0000-0002-8131-513X")),
           person("Elaina", "Kenyon",
             role = c("ctb"), comment = c(ORCID = "0000-0001-8781-2391"))
           )
Depends: R (>= 2.10)
Imports: httk, rmarkdown, knitr, Rdpack
RdMacros: Rdpack
Suggests: dplyr, tidyverse, xlsx, Metrics, ggplot2, ggforce, ggpubr,
        ggrepel, viridis, ggpubr, grid, ggh4x, readr, ggforce, tidyr,
        stringr, pracma, cgwtools, openxlsx, ggstar, latex2exp, smatr,
        reshape,
        gdata,censReg,gmodels,gplots,scales,colorspace,gridExtra,
        rvcheck
License: MIT + file LICENSE
LazyData: true
LazyDataCompression: xz
Encoding: UTF-8
VignetteBuilder: knitr
RoxygenNote: 7.3.3
URL: https://chemicalinsights.ul.org/
NeedsCompilation: no
Packaged: 2026-10-19 11:02:08 UTC; root
Author: John Wambaugh [aut, cre] (ORCID:
        <https://orcid.org/0000-0002-4024-534X>), Robert Pearce [aut]
        (ORCID: <https://orcid.org/0000-0003-3168-4049>), Caroline Ring
        [aut] (ORCID: <https://orcid.org/0000-0002-0463-1251>), Greg
        Honda [aut] (ORCID: <https://orcid.org/0000-0001-7713-9850>),
        Matt Linakis [aut] (ORCID:
        <https://orcid.org/0000-0003-0526-2395>), Dustin Kapraun [aut]
        (ORCID: <https://orcid.org/0000-0001-5570-6383>), Kimberly
        Truong [aut] (ORCID: <https://orcid.org/0000-0003-1716-1006>),
        Meredith Scherer [aut] (ORCID:
        <https://orcid.org/0000-0002-9785-7363>), Annabel Meade [aut]
        (ORCID: <https://orcid.org/0000-0002-5452-8797>), Celia Schacht
        [aut] (ORCID: <https://orcid.org/0000-0002-8131-513X>), Elaina
        Kenyon [ctb] (ORCID: <https://orcid.org/0000-0001-8781-2391>)
Maintainer: John Wambaugh <john.wambaugh@UL.org>
Config/pak/sysreqs: cmake make libuv1-dev
Repository: https://wambaughul.r-universe.dev
Date/Publication: 2025-12-10 21:39:07 UTC
RemoteUrl: https://github.com/cran/httkexamples
RemoteRef: HEAD
RemoteSha: f98d97a130b1c257e689749454589ee7fea43860