https://wambaughul.r-universe.devRecent package updates in wambaughulR-universehttps://github.com/wambaughul.pnghttps://wambaughul.r-universe.devWed, 10 Dec 2025 21:39:07 GMTjohn.wambaugh@ul.org (John Wambaugh)High throughput toxicokinetics ("HTTK") is the combination of 1) chemical-specific in vitro measurements or in silico predictions and 2) generic mathematical models, to predict absorption, distribution, metabolism, and excretion by the body. HTTK methods have been described by Pearce et al. (2017) (<doi:10.18637/jss.v079.i04>) and Breen et al. (2021) (<doi:10.1080/17425255.2021.1935867>). Here we provide examples (vignettes) applying HTTK to solve various problems in bioinformatics, toxicology, and exposure science. In accordance with Davidson-Fritz et al. (2025) (<doi:10.1371/journal.pone.0321321>), whenever a new HTTK model is developed, the code to generate the figures evaluating that model is added as a new vignettte.https://github.com/r-universe/wambaughul/actions/runs/39240881987Wed, 10 Dec 2025 21:39:07 GMThttkexamples0.0.1successhttps://wambaughul.r-universe.devhttps://github.com/cran/httkexamplesVa_Pearce2017.RmdVa_Pearce2017.htmlPearce et al. (2017): Updated v79i04.R Examples2025-12-10 21:39:072025-12-10 21:39:07Vb_Ring2017.RmdVb_Ring2017.htmlRing et al. (2017) HTTK-Pop: Generating subpopulations2025-12-10 21:39:072025-12-10 21:39:07Vc_Pearce2017.RmdVc_Pearce2017.htmlPearce et al. (2017): Evaluation of Tissue Partitioning2025-12-10 21:39:072025-12-10 21:39:07Vd_Wambaugh2018.RmdVd_Wambaugh2018.htmlWambaugh et al. (2018): Evaluating In Vitro-In Vivo Extrapolation2025-12-10 21:39:072025-12-10 21:39:07Ve_Frank2019.RmdVe_Frank2019.htmlFrank et al. (2018): Neuronal Network IVIVE2025-12-10 21:39:072025-12-10 21:39:07Vf_Honda2019.RmdVf_Honda2019.htmlHonda et al. (2019): Updated Armitage et al. (2014) Model2025-12-10 21:39:072025-12-10 21:39:07Vg_Wambaugh2019.RmdVg_Wambaugh2019.htmlWambaugh et al. (2019): Uncertainty Monte Carlo2025-12-10 21:39:072025-12-10 21:39:07Vh_Linakis2020.RmdVh_Linakis2020.htmlLinakis et al. (2020): High Throughput Inhalation Model2025-12-10 21:39:072025-12-10 21:39:07Vi_Kapraun2022.RmdVi_Kapraun2022.htmlKapraun et al. (2022): Generic Human Gestational Model2025-12-10 21:39:072025-12-10 21:39:07Vj_Truong2025.RmdVj_Truong2025.htmlTruong et al. (2025): Full Human Gestational IVIVE2025-12-10 21:39:072025-12-10 21:39:07Vk_WambaughSubmitted.RmdVk_WambaughSubmitted.htmlWambaugh (Submitted): HTTK for PFAS2025-12-10 21:39:072025-12-10 21:39:07Vl_MeadeSubmitted.RmdVl_MeadeSubmitted.htmlMeade (submitted): High Throughput Dermal Exposure Model2025-12-10 21:39:072025-12-10 21:39:07Vm_SchererSubmitted.RmdVm_SchererSubmitted.htmlCharacterizing Accuracy of Model Predictions for Chemical Concentration in High Throughput Screening Assays2025-12-10 21:39:072025-12-10 21:39:07